The Gene 2
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The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). "Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself." –Ken Burns “Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. “Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. “A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).
This Book Is Written Strictly In Accordance With The Revised Common Core Syllabus Recommended By Andhra Pradesh State Council Of Higher Education. It Also Caters The Needs Of Undergraduate Students Of Other Indian Universities. This Book Covers Gymnosperms, Plant Anatomy, Genetics And Ecology. Recent Developments In The Subject Matter Have Been Incorporated In The Book. The Book Has A Systematic Presentation. Important Questions And Their Solutions Are Given At The End Of Each Chapter. Every Care Has Been Taken To Present The Subject In A Simple And Lucid Language. The Book Is Profusely Illustrated.This Book Is Written Strictly In Accordance With The Revised Common Core Syllabus Recommended By Andhra Pradesh State Council Of Higher Education. It Also Caters The Needs Of Undergraduate Students Of Other Indian Universities. This Book Covers Gymnosperms, Plant Anatomy, Genetics And Ecology. Recent Developments In The Subject Matter Have Been Incorporated In The Book. The Book Has A Systematic Presentation. Important Questions And Their Solutions Are Given At The End Of Each Chapter. Every Care Has Been Taken To Present The Subject In A Simple And Lucid Language. The Book Is Profusely Illustrated. This Book Is Written Strictly In Accordance With The Revised Common Core Syllabus Recommended By Andhra Pradesh State Council Of Higher Education.It Also Caters The Needs Of Undergraduate Students Of Other Indian Universities. This Book Covers Gymnosperms, Plant Anatomy, Genetics And Ecology. Recent Developments In The Subject Matter Have Been Incorporated In The Book. The Book Has A Systematic Presentation. Important Questions And Their Solutions Are Given At The End Of Each Chapter. Every Care Has Been Taken To Present The Subject In A Simple And Lucid Language. The Book Is Profusely Illustrated. This Book Is Written Strictly In Accordance With The Revised Common Core Syllabus Recommended By Andhra Pradesh State Council Of Higher Education. It Also Caters The Needs Of Undergraduate Students Of Other Indian Universities.This Book Covers Gymnosperms, Plant Anatomy, Genetics And Ecology. Recent Developments In The Subject Matter Have Been Incorporated In The Book. The Book Has A Systematic Presentation. Important Questions And Their Solutions Are Given At The End Of Each Chapter. Every Care Has Been Taken To Present The Subject In A Simple And Lucid Language. The Book Is Profusely Illustrated.
The third edition of this bestseller examines the principles of artificial intelligence and their application to engineering and science, as well as techniques for developing intelligent systems to solve practical problems. Covering the full spectrum of intelligent systems techniques, it incorporates knowledge-based systems, computational intelligence, and their hybrids. Using clear and concise language, Intelligent Systems for Engineers and Scientists, Third Edition features updates and improvements throughout all chapters. It includes expanded and separated chapters on genetic algorithms and single-candidate optimization techniques, while the chapter on neural networks now covers spiking networks and a range of recurrent networks. The book also provides extended coverage of fuzzy logic, including type-2 and fuzzy control systems. Example programs using rules and uncertainty are presented in an industry-standard format, so that you can run them yourself. The first part of the book describes key techniques of artificial intelligence—including rule-based systems, Bayesian updating, certainty theory, fuzzy logic (types 1 and 2), frames, objects, agents, symbolic learning, case-based reasoning, genetic algorithms, optimization algorithms, neural networks, hybrids, and the Lisp and Prolog languages. The second part describes a wide range of practical applications in interpretation and diagnosis, design and selection, planning, and control. The author provides sufficient detail to help you develop your own intelligent systems for real applications. Whether you are building intelligent systems or you simply want to know more about them, this book provides you with detailed and up-to-date guidance. Check out the significantly expanded set of free web-based resources that support the book at: http://www.adrianhopgood.com/aitoolkit/
TheArti?cialLifetermappearedmorethan20yearsagoinasmallcornerofNew Mexico, USA. Since then the area has developed dramatically, many researchers joining enthusiastically and research groups sprouting everywhere. This frenetic activity led to the emergence of several strands that are now established ?elds in themselves. We are now reaching a stage that one may describe as maturer: with more rigour, more benchmarks, more results, more stringent acceptance criteria, more applications, in brief, more sound science. This, which is the n- ural path of all new areas, comes at a price, however. A certain enthusiasm, a certain adventurousness from the early years is fading and may have been lost on the way. The ?eld has become more reasonable. To counterbalance this and to encourage lively discussions, a conceptual track, where papers were judged on criteria like importance and/or novelty of the concepts proposed rather than the experimental/theoretical results, has been introduced this year. A conference on a theme as broad as Arti?cial Life is bound to be very - verse,but a few tendencies emerged. First, ?elds like ‘Robotics and Autonomous Agents’ or ‘Evolutionary Computation’ are still extremely active and keep on bringing a wealth of results to the A-Life community. Even there, however, new tendencies appear, like collective robotics, and more speci?cally self-assembling robotics, which represent now a large subsection. Second, new areas appear.
High-throughput genomics has been increasingly generating the massive amount of genome-wide data. With proper modeling methodologies, we can expect to archive a more comprehensive understanding of the regulatory mechanisms of biological systems. This work presents integrative approaches for the modeling and analysis of gene regulatory systems. In mammals, gene expression regulation is combinatorial in nature, with diverse roles of regulators on target genes. Microarrays (such as Exon Arrays) and RNA-Seq can be used to quantify the whole spectrum of RNA transcripts. ChIP-Seq is being used for the identification of transcription factor (TF) binding sites and histone modification marks. RNA interference (RNAi), coupled with gene expression profiles, allow perturbations of gene regulatory systems. Our approaches extract useful information from those genome-wide measurements for effectively modeling the logic of gene expression regulation. We present a predictive model for the prediction of gene expression from ChIP-Seq signals, based on quantitative modeling of regulator-gene association strength, principal component analysis, and regression-based model selection. We demonstrate the combinatorial regulation of TFs, and their power for explaining genome-wide gene expression variation. We also illustrate the roles of covalent histone modification marks on predicting gene expression and their regulation by TFs. We present a dynamical model of gene expression profiling, and derive the perturbed behaviors of the ordinary differential equation (ODE) system. Based on that, we present a regularized multivariate regression method for inferring the gene regulatory network of a stable cell type. We model the sparsity and stability of the network by a regularization approach. We applied the approaches to both a simulation data set and the RNAi perturbation data in mouse embryonic stem cells.
This new clinical resource brings you a state-of-the-art comprehensive review on every clinical condition encountered in pediatric nephrology in one concise, clinically focused text. International experts provide you with the latest on epidemiology, diagnosis, investigations, management, and prognosis for a full range of pediatric kidney disorders. A full-color, highly visual, meticulously crafted format, makes this material remarkably easy for you to access and apply. Comprehensive Pediatric Nephrology also serves as an ideal resource for board review study for the ABP subspecialty boards in pediatric nephrology. Just the right amount of "need-to-know" basic science coupled with practical clinical guidance for every disorder helps you make efficient, informed decisions. The book provides a much needed update on the genetic origins of pediatric kidney disorders. Chapters about glomerulonephritis, nephrotic syndrome, and tubular disorders provide an orientation in the pathophysiology, differential diagnosis, and treatment of these heterogeneous disease entities. Disease specific chapters include diagnostic work-up, laboratory evaluation, and management of disorders and complications, making this necessary information readily accessible. The prevention and management of pediatric chronic renal failure and its complications are comprehensively covered in many detailed chapters. Four chapters devoted to childhood hypertension offer you insights into an increasingly prevalent condition among pediatric patients so you can treat them more effectively. A chapter on the role of the interventional radiologist in pediatric nephrology keeps you apprised of the latest advances in a key area in the field. The function of complementary and alternative medicine in patients with renal disease is reviewed for the first time in a standard pediatric nephrology textbook. A consistent organization throughout and a full-color layout lets you find diagnostic guidance quickly.
This book constitutes the refereed proceedings at PAKDD Workshops 2013, affiliated with the 17th Pacific-Asia Conference on Knowledge Discovery and Data Mining (PAKDD) held in Gold Coast, Australia in April 2013. The 47 revised full papers presented were carefully reviewed and selected from 92 submissions. The workshops affiliated with PAKDD 2013 include: Data Mining Applications in Industry and Government (DMApps), Data Analytics for Targeted Healthcare (DANTH), Quality Issues, Measures of Interestingness and Evaluation of Data Mining Models (QIMIE), Biologically Inspired Techniques for Data Mining (BDM), Constraint Discovery and Application (CDA), Cloud Service Discovery (CloudSD).
Volume 1 of the series Changing the Global Approach to Medicine introduced the concept of RNA Vector Therapy, the innovative utilization of virus-like devices to deliver RNA molecules to protein deficient cells to provide a directed medical therapy. Volume 2 greatly expands this approach to configuring enhanced virus-like transport devices to deliver various forms of therapeutic materials to specific cell types. Medial Vector Therapy includes the delivery of DNA, chemotherapy and other drug molecules, oxygen, and nutrients as well as various forms of RNA to the cells that require such therapeutic interventions. This ingenious new approach to the management of challenging diseases has the distinct advantage of administering a broad spectrum of therapeutic elements directly to the cells in need, but dramatically limits the side effects by not exposing other cells in the body to the potential harmful effects of such therapies. Also introduced in this text are the innovative concepts the Quantum Gene and the Quadsistor.
In recent years, a great number of publications have explored the use of genetic algorithms as a tool for designing fuzzy systems. Genetic Fuzzy Systems explores and discusses this symbiosis of evolutionary computation and fuzzy logic. The book summarizes and analyzes the novel field of genetic fuzzy systems, paying special attention to genetic algorithms that adapt and learn the knowledge base of a fuzzy-rule-based system. It introduces the general concepts, foundations and design principles of genetic fuzzy systems and covers the topic of genetic tuning of fuzzy systems. It also introduces the three fundamental approaches to genetic learning processes in fuzzy systems: the Michigan, Pittsburgh and Iterative-learning methods. Finally, it explores hybrid genetic fuzzy systems such as genetic fuzzy clustering or genetic neuro-fuzzy systems and describes a number of applications from different areas. Genetic Fuzzy System represents a comprehensive treatise on the design of the fuzzy-rule-based systems using genetic algorithms, both from a theoretical and a practical perspective. It is a valuable compendium for scientists and engineers concerned with research and applications in the domain of fuzzy systems and genetic algorithms.
Toxigenic Fusarium species and ochratoxigenic fungi are responsible for various plant diseases which have important consequential effects on both human and animal health worldwide. The development of rapid, robust and sensitive detection methods based on new molecular technologies is urgently needed in order to identify fungal contamination in the field and quantify toxin accumulation in food and animal feed. Most of the contributions in this special issue are from results obtained through the EU 5th Framework project (QLKI-CT-1998-01380) "DETOX-FUNGI: early detection of toxigenic Fusarium species and ochratoxi genic fungi in plant products", which has strongly stimulated interaction and co-operation between many European scientists. Valuable contributions from other scientists have guaranteed a complete overview of this stimulating and interesting topic. This is the third special issue published in the European Journal of Plant Pathology concerning my cotoxigenic fungi under the aegis of COST Action 835 'Agriculturally Important Toxigenic Fungi'. The first two dealt with 'Mycotoxins in Plant Disease' (Vol. 108(7) 2002) and 'Epidemiology of Mycotoxin Pro ducing Fungi' (Vol. 109(7) 2003). The present issue contains contributions which cover aspects of molecular diversity, phylogeny and PCR-detection of toxigenic Fusarium species and various ochratoxigenic fungi. We hope these will prove helpful to researchers involved in similar work and will stimulate the future studies required for the early detection of these fungi, which is so essential for overcoming the health risks associated with mycotoxin-contaminated food products.